A small, solid body shaped for ready introduction into one of the orifices of the body other than the oral cavity (e.g., rectum, urethra, vagina), made of a substance, usually medicated, that is solid at ordinary temperatures but melts at body temperature. SUPPOSITORY It is solid dosage form meant to be inserted into Body cavity like rectum, urethra, vagina, where they melt or soften to release the drugs and produce their local or systemic effect. It is comes under semi solid preparation because it is prepared by melting all ingredients (bases and other additives along with active ingredient). All types of suppositories are melt at normal body … •A lipophilic drug that is distributed in a fatty suppository base in low concentration has less tendency to escape to The selection of a suppository base is dependent upon a number of physicochemical variables, including the solubility characteristics of the drug. A suppository, which is a general term for a solid dose of medicine that is inserted into the anus or the vagina, can contain different medications, from contraceptives to medication to kill off yeast infections. Suppository definition, a solid, conical mass of medicinal substance that melts upon insertion into the rectum or vagina. Surfactant base. Suppositories should melt at just below body temperature (37 C), which allows for erosion of the dosage form and release of the API. 6. . It may be used to stimulate a bowel movement, but often serves as a vehicle for medicines to be absorbed. The first is the fat- or oil-type base, which must melt at body temperature to release its medication. Name the Oleaginous Suppository Bases that are Cocoa Butter substitutes. Base, in chemistry, any substance that in water solution is slippery to the touch, tastes bitter, changes the color of indicators (e.g., turns red litmus paper blue), reacts with acids to form salts, and promotes certain chemical reactions (base catalysis). Glycerinated Gelatin Polyethylene Glycols. The shape, volume and consistency of suppositories are suitable for rectal application. Suppository bases can be broadly divided into following categories- A. Oleaginous bases. the suppository base and in anticipating drug release from that base. A suppository is a medication that is inserted into the rectum, vagina, or urethra to be broken down and absorbed by the body. This is then poured into the mold, refrigerated to harden, cut into pieces the size of the patient's pinky finger, and inserted as needed. These products are so formulated that after insertion, they will either melt or dissolve in … All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. a solid mass of medicinal substance that melts upon insertion into the rectum or vagina. Rectal suppositories are solid forms of medication that are inserted into the rectum. See more. Suppositories have a base made from substances like gelatin or cocoa butter that surrounds the drug. Drug weight=3 gm. suppository - a small plug of medication designed for insertion into the rectum or vagina where it melts medicament, medication, medicinal drug, medicine - (medicine) something that treats or prevents or alleviates the symptoms of disease Based on WordNet 3.0, Farlex clipart collection. Also called. Glycerinated Gelatin is a useful suppository base, particularly for vaginal suppositories. They are prepared by moulding or compression. Hard fat suppository bases melt at approximately body temperature. Water soluble/water miscible bases are those containing glycerinated gelatin or the polyethylene glycol (PEG) polymers. There are three types of suppositories, each to insert into a different sections: Rectal suppositories into the rectum, vaginal suppositories into the vagina, and urethral suppositories into the urethra of a male. Definition Suppositories are solid single-dose preparations intended for rectal application. ( sŭ-poz'i-tō'rē ), A small solid preparation shaped for ready introduction into one of the orifices of the body other than the oral cavity (for example, rectum, urethra, vagina), made of a substance, usually medicated, which is solid at room temperatures but melts at body temperature. Suppositive definition, of the nature of or involving supposition; suppositional. C. Emulsifying bases. Vaginal suppositories are one method of administering a drug to treat a specific disease or condition, or for contraceptive purposes. What is the main advantage of a polyethylene glycol Suppository Base over Oleaginous Bases? They come in different shapes and sizes, but they are usually narrowed at … Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube. C. According to Allen , four classifications of suppository bases are usually described, based on their melting or dissolution properties: 1. Suppository bases usually employed are cocoa butter, glycerinated gelatin, hydrogenated vegetable oils, mixtures of PEGs of various molecular weights, and fatty acid esters of PEG (15). Suppository bases usually used are theobroma oil, glycerinated gelatin, hydrogenated vegetable oils, … 1. suppository - a small plug of medication designed for insertion into the rectum or vagina where it melts. Now the practical weight of the six suppositories is 14 gm and the total amount of the drug in all suppositories is equal to 6 * 500=3000 mg=3 g. Practical weight=14 gm. Water-soluble bases dissolve in rectal fluids and Dictionary, Encyclopedia and Thesaurus - The Free Dictionary, the webmaster's page for free fun content, Suppress, Obscure, Secure, Reduce, and Assault, Suppress, Obscure, Secure, Reduce, Remove. Suppository bases usually used are theobroma oil, glycerinated gelatin, hydrogenated vegetable oils, mixtures of polyethylene glycols of various molecular weights, and fatty acid esters of polyethylene glycol. suppositories: (sŭ-pŏz′ĭ-tō-rē) plural. Learn more. So, by the addition of the drug , 1 gm of the suppository base is displaced. Suppository uses include asthma, allergies, and pain. ry. Suppositories have a base made from substances like gelatin or cocoa butter that surrounds the drug. It is suitable for use with a wide range of medicaments including alkaloids, boric acid, and zinc oxide. SUPPOSITORY BASE Lipid–Water Solubility •The lipid–water partition coefficient of a drug is an important consideration in the selection of the suppository base and in anticipating drug release from that base. Specifications for Suppository Bases 1 Origin & Chemical Composition:  A brief description of the composition of the base reveals the sours of the origin (natural or synthetic or modified natural products). As the warmth of your body melts the … This contraction will produce a hole in the open end of the suppository. Such a hole is undesirable. So, the weight of the suppository base is 14 – 3=11 gm. 67. See more. Name some Water-Soluble and Water-Miscible Suppository Bases. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional. The base of the suppository is a combination of coconut oil and cocoa butter, to which is added the desired combination of medicated oils, powdered herbs, and tinctures. https://medical-dictionary.thefreedictionary.com/Suppository+bases. Definition of suppository : a solid but readily meltable cone or cylinder of usually medicated material for insertion into a bodily passage or cavity (such as the rectum) Examples of suppository in a Sentence Some mixtures and bases have very pronounced contractions (e.g., cocoa butter, PEG) while others have much smaller ones (e.g., glycerinated gelatin, MBK®). When suppository mixtures and bases cool, they contract. A tablet inserted into the anus or vagina that dissolves to administer a drug treatment or anesthesia. A suppository is a dosage form used to deliver medications by insertion into a body orifice where it dissolves or melts to exert local or systemic effects. an easily fusible medicated mass for introduction into the rectum, urethra, or vagina. © 2003-2012 Princeton University, Farlex Inc. SUPPOSITORIES - Definition - merits - limitations - formulations - suppository bases - compounding - labeling - displacement value - evaluation - solid or stiffened ... – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 3cf72b-ODMzZ Global fatty bases for suppositories market forecast is predicted tobe $6,565.1 million by 2027 at a healthy CAGR of 2.7%. Also called. Tableted suppositories or inserts. https://www.thefreedictionary.com/Suppository+bases, A small plug of medication designed to melt at body temperature within a body cavity other than the mouth, especially the rectum or vagina. 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